spray drying of mannitol as a drug carrier—the

The Role of Carrier in Dry Powder Inhaler

Dec 14 2011In this study mannitol was crystallized from different binary mixtures of acetone/water and its carrier role in DPI formulations of salbutamol sulfate was investigated (Kaialy et al 2010) Mannitol particles produced by spray drying have been used commercially (Aridol TM) in bronchial provocation test (mannitol particle itself as an active

Preparation of polymer

METHODS: (1) The organic solution containing quinine a model of bitter compound and poorly water-soluble polymers and (2) sugar alcohol (mannitol) aqueous solution were separately flown in tubes and two solutions were spray dried through two-solution type spray nozzle to prepare polymer-blended quinine nanocomposite particles

Spray

Mannitol or leucine were incorporated as spray-drying excipients to verify their effect on the final properties of drug-loaded konjac glucomannan microparticles The obtained results indicate that konjac glucomannan is a suitable material for the preparation of inhalable microparticles for antitubercular therapy upon processing by spray-drying

Tribo

Methods: Salbutamol sulphate (SBS) particles engineered via spray-drying and jet milling were used as model APIs D-mannitol was selected as a model carrier The materials were characterized concerning their different particle properties and their charge was analysed alone and in blends before and after flow over a stainless-steel pipe

Information Bulletin Number 59/2010

Spray drying is a simple rapid repro-ducible economic and easy to scale-up production process [2] that has been in-tensively studied for pharmaceuticals and excipients for pulmonary drug de-livery in dry powder inhalation systems Laboratory Scale Spray Drying Of Inhalable Drugs: A Review particles based on the available RDD

Spray Drying Microcapsules

∙ Controlled Drug Release for efficient use of medicine ∙ Protection of a sensitive product with packing them in a carrier (e g pro-tein peptides and microorganisms) ∙ Easier handling and dosing of expensive products in a cheaper carrier The Mini Spray Dryer B-290 offers quick and gentle drying of

Tribo

Apr 09 2019Salbutamol sulphate (SBS) particles engineered via spray-drying and jet milling were used as model APIs D-mannitol was selected as a model carrier The materials were characterized concerning their different particle properties and their charge was analysed alone and in blends before and after flow over a stainless-steel pipe

Spray Drying: An Overview

Spray drying is a well-known method of particle production which comprises the transformation of a fluid material into dried particles taking advantage of a gaseous hot drying medium with clear advantages for the fabrication of medical devices In fact it is quite common the production of microspheres and microcapsules designed for drug delivery systems

Mannitol

Jul 07 2014Mannitol is classified as a sugar alcohol and is derived from a sugar (mannose) by reduction Other widely known polyols are xylitol and sorbitol Mannitol and sorbitol are isomers differing only in the orientation of the hydroxyl group on carbon two The physical properties of mannitol make it suitable for use as a bulking agent in tableting

Budesonide dry powder for inhalation: effects of leucine

OBJECTIVE: The aim of this study was to develop a budesonide dry powder for inhalation using l-leucine and l-leucine - sieved mannitol as a carrier MATERIALS AND METHODS: Budesonide and l-leucine were co-spray dried at a mass ratio of 1:50 then blended with various mass ratios of sieved mannitol in the range of 20-80

SPRAY

This study describes developments and in vitro characterisation of lipid microparticles prepared using spray-drying for drug delivery to the lung via dry powder inhalers Bioadhesive formulations such as prochitosome or chitosome powders have been introduced to overcome the drawbacks of liposome instability and potentially provide significant increase in the residence time of drug in the lung

The characterization and comparison of spray

Background: Following the production of spray-dried mannitol powders it is essential that the polymorphic content of each individual product is completely characterized The implications of the polymorphic behavior of mannitol are immense The appearance or disappearance of a crystalline form within a dosage form can have costly repercussions and lead to a dosage form being withdrawn

Spray

Mannitol or leucine were incorporated as spray-drying excipients to verify their effect on the final properties of drug-loaded konjac glucomannan microparticles The obtained results indicate that konjac glucomannan is a suitable material for the preparation of inhalable microparticles for antitubercular therapy upon processing by spray-drying

Effect of thermal and shear stresses in the spray drying

Pulmonary delivery of small interfering RNAs (siRNAs) has shown promising results for the treatment of lung diseases with gene disorders The aim of this work was to evaluate the effect of processing-induced thermal and shear stresses during the spray drying process on the solid-state properties the chemical integrity and the bioactivity of spray-dried siRNA powder intended for inhalation

Compaction Stability of Spray

For some DC excipients made by spray-drying like spray-dried DC monohydrate lactose a decrease of compaction properties has been observed and was attributed to the crystallization of the amorphous part 3 We state the hypothesis that such phenomena is not possible with mannitol as there is no amorphous mannitol at ambient temperature

dry powder inhaler dosing fine particle fraction

In this study interparticle interactions have been modified by targeting the surface topography of the carrier or rather the contact area between drug and carrier using spray drying Because lactose is susceptible to spray drying resulting in partial or full amorphicity mannitol was used here

Frontiers

Mar 20 2019Therapeutic bacteriophages offer a potential alternative approach in the treatment of drug resistant bacteria In the present study we examine the ability of atmospheric spray freeze-drying (ASFD) to process bacteriophage D29 into a solid dry formulation Bacteriophage D29 is of particular interest due to its ability to infect Mycobacterium tuberculosis

Imagine the Superiority of Dry Powder Inhalers from

2 1 2 Spray-Dried Lactose Spray-drying (SD) is a unit operation that transfers a fluid supply to a dried particulate The feed can be simply a solution a colloidal dispersion (e g emulsion liposome) or a coarse or fine suspension which is initially atomized to a spray form that is placed instantly into thermal contact by means of a hot air leading to quick evaporation of droplets to

Spray

Abstract Spray-drying is proposed in this work as the technique to produce konjac glucomannan microparticles aimed at an application in lung tuberculosis therapy Microparticles were developed to provide direct lung delivery of an association of two first-line antitubercular drugs isoniazid and rifabutin by inhalation Mannitol or leucine were incorporated as spray-drying excipients to

Formulation considerations for dry powder inhalers

Aug 04 201437 Littringer EM Mescher A Eckhard S et al Spray drying of mannitol as a drug carrier – the impact of process parameters on product properties Drying Technol 30(1) 114–124 (2012) Crossref CAS Google Scholar 38 Chan H Chew NY Novel alternative methods for the delivery of drugs for the treatment of asthma Adv

The crucial role of leucine concentration on spray dried

Generally DPI formulations show low fine particle fraction (FPF) due to poor detachment of drug particles from carrier during inhalation L-Leucine with varying concentrations (ranging from 0 to 10% w/w) were introduced into a 60%w/v mannitol solution where the solutions were then spray dried to achieve a new processed carrier The spray dried samples were blended with Albuterol sulfate to

Formulation Development of Porous Mannitol carrier

Dec 20 2019work was to improve the dissolution rate of poorly water soluble drugs by using porous carrier drug delivery system Templating based spray drying methodology was used to prepare porous mannitol Drug (Telmisartan Ezetimibe) loaded porous mannitol carriers then characterized by P-XRD DSC SEM BET surface area analysis and ATR-FTIR

Formulation characteristics and aerosolization

Nov 20 2008A group of dry powder inhalations (DPIs) of AZI were designed by varying the type and amount of carriers (i e lactose mannitol L-leucine glycine) to select the best composition and further investigate into the relationship between the composition the physical properties and the aerosolization performance Among the four candidate carriers L-leucine was found to be the best choice when

Budesonide dry powder for inhalation: effects of leucine

OBJECTIVE: The aim of this study was to develop a budesonide dry powder for inhalation using l-leucine and l-leucine - sieved mannitol as a carrier MATERIALS AND METHODS: Budesonide and l-leucine were co-spray dried at a mass ratio of 1:50 then blended with various mass ratios of sieved mannitol in the range of 20-80